Synthesis of some novel hydrazone derivatives and evaluation of their antituberculosis activity

*Author to whom correspondence should be addressed; e-mail: [email protected], phone: +90 222 335 05 80 / 3774, fax: +90 222 335 07 50. INTRODUCTION In spite of a 5000 year history, tuberculosis (TB) remains the leading single-agent infectious disease killer in the world. Approximately one third of the world’s population is infected with TB bacilli, and each year almost 8 million people develop active TB and 2 million die as a result of TB. The major challenges for tuberculosis control are the development of multidrug-resistant tuberculosis (MDRTB) strains and the increasing numbers of immunocompromised